HIV/AIDS
New HIV/AIDS study findings have been published by scientists at University of Oxford
Published in AIDS Weekly, February 25th, 2008
Data detailed in 'Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals' have been presented. According to recent research from Oxford, the United Kingdom, "HIV-1 provirus, either as a chromosomal integrant or as an episomal plasmid in HeLa cells, forms a transcription-dependent gene loop structure between the 5'LTR promoter and 3'LTR poly(A) signal. Flavopiridol-mediated inhibition of RNA polymerase II elongation blocks 5' to 3'LTR juxtaposition, indicating that this structure is maintained during transcription."
"Analysis of mutant or hybrid HIV-1 plasmids demonstrates that replacement of the 5'LTR...
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Source: AIDS Weekly (2008-02-25)
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