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HIV/AIDS Immunology

Studies from Pennsylvania State University, Center of Molecular Immunology in the area of HIV/AIDS immunology described

Published in AIDS Weekly, March 10th, 2008

A new study, 'The receptor tyrosine kinase RON represses HIV-1 transcription by targeting RNA polymerase II processivity,' is now available. According to a study from the United States, "Efficient HIV-1 transcription requires the induction of cellular transcription factors, such as NF-kappaB, and the viral factor Tat, which through the recruitment of P-TEFb enhances processive transcription. However, whether cellular signals repress HIV-1 transcription to establish proviral latency has not been well studied."

"Previously, it has been shown that the receptor tyrosine kinase RON inhibits HIV transcription. To gain insights into the biochemical mechanisms by which RON...

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