HIV/AIDS

Data on HIV/AIDS discussed by C. Mihailidis and colleagues

Published in AIDS Weekly, March 31st, 2008

"Although the V118I mutation in reverse transcriptase causes a reduced incorporation of zidovudine and lamivudine into transcribed viral DNA, it also decreases ATP-mediated pyrophosphorylysis. In this manner, its overall impact on enzymatic activity appears to be neutral when assessed in vitro," researchers in London, the United Kingdom report.

"Nevertheless, V118I remains identified as a resistance mutation by a number of commonly utilised resistance mutation algorithms. A large clinical database was queried to identify antiretroviral-naive patients with V118I as the sole resistance associated mutation. Each index patient was matched to five control patients with no...

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Source: AIDS Weekly (2008-03-31)

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