HIV/AIDS

Data on HIV/AIDS published by researchers at National Cancer Institute

Published in AIDS Weekly, April 7th, 2008

According to recent research from the United States, "In retroviruses, the first nucleotide added to the tRNA primer defines the end of the U5 region in the right long terminal repeat, and the subsequent removal of this tRNA primer by RNase H exactly defines the U5 end of the linear double-stranded DNA. In most retroviruses, the entire tRNA is removed by RNase H cleavage at the RNA/DNA junction."

"However, the RNase H domain of human immunodeficiency virus type I (HIV-1) reverse transcriptase cleaves the tRNA I nucleotide from the RNA/DNA junction at the U5/primer binding site (PBS) junction, which leaves an rA residue at the U5 terminus. We made sequence changes at the...

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Source: AIDS Weekly (2008-04-07)

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