HIV/AIDS

Research on HIV/AIDS detailed by scientists at Yokohama City University, Medical Department

Published in AIDS Weekly, April 14th, 2008

According to recent research from Yokohama, Japan, "Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. The discovery of cellular factors that participate in HIV-1 replication pathways has provided further insight into the molecular basis of virus-host cell interactions."

"Here, we report that the suppressor of cytokine signaling 1 (SOCS1) is an inducible host factor during HIV-1 infection and regulates the late stages of the HIV-1 replication pathway. SOCS1 can directly bind to the matrix and nucleocapsid regions of the HIV-1 p55 Gag polyprotein and enhance its stability and trafficking,...

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Source: AIDS Weekly (2008-04-14)

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