Cytomegalovirus

Karolinska University, Medical Department reports research in cytomegalovirus

Published in AIDS Weekly, April 21st, 2008

According to a study from Stockholm, Sweden, "Leukotrienes (LTs) are powerful proinflammatory lipid mediators that may play a central role in cardiovascular diseases, including arteriosclerosis, myocardial infarction, and stroke. Owing to restricted expression of 5-lipoxygenase (5-LO), the enzyme required for their synthesis, LTs are almost exclusively produced by myeloid cells."

"Here, we report that human cytomegalovirus ( HCMV) infection of human vascular smooth muscle cells (SMCs) increases 5-LO mRNA levels by up to 170-fold in a dose- and time-dependent manner. Infected cells expressed 5-LO protein, as shown by immunohistochemistry, enabling them to synthesize...

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Source: AIDS Weekly (2008-04-21)

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