HIV/AIDS

New HIV/AIDS findings from L. Du and co-researchers published

Published in AIDS Weekly, April 21st, 2008

According to recent research from Shanghai, People's Republic of China, "HIV-1 integrase (IN) is composed of three domains, the N-terminal domain (NTD, residues 1-50), the catalytic core domain (CCD, residues 51-212), and the C-terminal domain (CTD, residues 213288). All the three domains are required for the two known integration reactions."

"CCD contains the catalytic triad and is believed to bind viral DNA specifically, and CTD binds viral DNA in a nonspecific manner. As no clear evidence has confirmed the involvement of NTD in DNA binding directly, NTD has not been seriously considered and less is known about its function in viral replication. In the current work,...

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Source: AIDS Weekly (2008-04-21)

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