HIV/AIDS
Scientists at University of Pittsburgh detail research in HIV/AIDS
Published in AIDS Weekly, April 21st, 2008
According to a study from the United States, "Previous biochemical studies have demonstrated that synergy between non-nucleoside reverse transcriptase (RT) inhibitors (NNRTI) and nucleoside RT inhibitors (NRTIs) is due to inhibition by the NNRTI of the rate at which HIV-1 RT facilitates ATP-mediated excision of NRTIs from chain-terminated template/ primers (T/ P). However, these studies did not take into account the possible effects of NNRTI on the ribonuclease H (RNase H) activity of RT, despite recent evidence that suggests an important role for this activity in the NRTI excision phenotype."
"Accordingly, in this study, we compared the ability of efavirenz to inhibit...
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Source: AIDS Weekly (2008-04-21)
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