HIV/AIDS
Reports summarize HIV/AIDS study results from J. Lalezari and co-researchers
Published in AIDS Weekly, April 28th, 2008
"HGS004 is a fully human immunoglobulin (Ig) G4 monoclonal antibody against CC chemokine receptor 5 (CCR5) with robust in vitro activity against a diverse panel of CCR5-tropic human immunodeficiency virus type 1 (HIV-1) isolates. A single-blind, randomized, placebo-controlled study was conducted in patients infected with CCR5-tropic HIV-1 to evaluate the safety, pharmacokinetics, and antiviral activity of HGS004," investigators in the United States report.
"Sixty-three subjects were randomized into 5 dose cohorts (0.4, 2, 8, 20, and 40 mg/kg) and received a single intravenous dose of HGS004 or placebo. HGS004 was well tolerated, and no dose-limiting toxicities were...
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Source: AIDS Weekly (2008-04-28)
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