HIV/AIDS
Research from Rutgers University in HIV/AIDS provides new insights
Published in AIDS Weekly, May 12th, 2008
"TMC278 is a diarylpyrimidine (DAPY) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is highly effective in treating wild-type and drug-resistant HIV-1 infections in clinical trials at relatively low doses (similar to 25-75 mg/day). We have determined the structure of wild-type HIV-1 RT complexed with TMC278 at 1.8 angstrom resolution, using an RT crystal form engineered by systematic RT mutagenesis," researchers in the United States report.
"This high-resolution structure reveals that the cyanovinyl group of TMC278 is positioned in a hydrophobic tunnel connecting the NNRTI-binding pocket to the nucleic acid-binding cleft. The crystal structures of TMC278 in...
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Source: AIDS Weekly (2008-05-12)
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