HIV/AIDS Cancer
Studies from G. Corona and co-researchers in the area of HIV/AIDS cancer published
Published in AIDS Weekly, May 12th, 2008
"The coadministration of protease inhibitors with anticancer drugs in the management of human immunodeficiency virus-related malignancies can cause potential drug-drug interactions. The effect of lopinavir/ritonavir (LPV/RTV) on the pharmacokinetics of irinotecan (CPT11) has been investigated in seven patients with Kaposi's sarcoma," scientists writing in the journal Clinical Pharmacology & Therapeutics report.
"Coadministration of LPV/RTV reduces the clearance of CPT11 by 47% (11.3 +/- 3.5 vs 21.3 +/- 6.3 l/h/m(2), P = 0.0008). This effect was associated with an 81% reduction (P = 0.02) of the AUC (area under the curve) of the oxidized metabolite APC...
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Source: AIDS Weekly (2008-05-12)
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