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HIV/AIDS
Findings from K. Danel and co-authors provide new insights into HIV/AIDS
May 12th, 2008
According to a study from Odense, Denmark, "This paper describes the synthesis and the antiviral activities of dimeric compounds derived from homo and asymmetric combinations of N-1 propynyloxymethyl analogues 1a,b of MKC-442, an N-1 4-iodobenzyloxymethyl analogue of TNK-651 5, potent contraceptive norgestrel and AZT." "They were obtained by Sonogashira reaction, 'click' chemistry or Pd-catalyzed oxidative coupling. The iodo precursor 5 turned out as a potent compound against wild type and mutated HIV-1 virus," wrote K. Danel and colleagues. The researchers concluded: "All dimeric compounds showed lower activity against HIV-1 than MKC-442, except the...
Source: AIDS Weekly (2008-05-12)
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