HIV/AIDS
Research conducted at University of Michigan, Medical Department has provided new information about HIV/AIDS
Published in AIDS Weekly, May 19th, 2008
According to a study from the United States, "Template switching between copackaged human immunodeficiency virus type 1 (HIV-1) genomic RNAs is genetically silent when identical RNAs are copackaged but yields recombinants when virions contain two distinct RNAs. Sequencing has revealed that errors at retroviral recombination junctions are infrequent, suggesting that template switching is not intrinsically mutagenic."
"Here, we tested the hypothesis that template switching may instead contribute to replication fidelity. This hypothesis predicts that reverse transcription of a single-copy gene will be more error prone than replication in the presence of a second copy. To...
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Source: AIDS Weekly (2008-05-19)
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