HIV/AIDS
Research on HIV/AIDS reported by scientists at University of North Carolina
Published in AIDS Weekly, May 19th, 2008
"The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3'S-Methylsuccinyl-betulinic acid (3'S-MSB, 4) exhibited potent anti-HIV activity with an EC50 value of 0.0087 mc M and a TI value of 6.3 x 10(3), which is comparable to the data for bevirimat (DSB, PA-457), a current clinical trials drug that was also derived from betulinic acid," wrote K. Qian and colleagues, University of North Carolina.
The researchers concluded: "The anti-HIV potency of 4 was slightly better...
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Source: AIDS Weekly (2008-05-19)
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