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HIV/AIDS Co-Infection

Findings from P. Munderi and co-researchers advance knowledge in HIV/AIDS co-infection

Published in AIDS Weekly, May 19th, 2008

"To compare the safety/tolerability of abacavir and nevirapine in HIV-infected adults starting antiretroviral (ARV) therapy in Uganda. Twenty-four-week randomized double-blind trial conducted with 600 symptomatic ARV-naive adults with CD4 < 200 cells/mm(3) allocated to zidovudine/lamivudine plus 300 mg abacavir (A) and nevirapine placebo (n = 300) or 200 mg nevirapine (N) and abacavir placebo (n = 300) twice daily," investigators in London, the United Kingdom report.

"The primary endpoint was any serious adverse event (SAE) definitely/probably or uncertain whether related to blinded nevirapine/abacavir. Secondary endpoints were adverse events leading to permanent...

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