HIV/AIDS Therapy
Research reports from V. Micheli and co-authors provide new insights into HIV/AIDS therapy
Published in AIDS Weekly, June 23rd, 2008
Researchers detail in 'Lopinavir/ritonavir pharmacokinetics in HIV/HCV-coinfected patients with or without cirrhosis,' new data in HIV/AIDS. "Liver disease may alter the pharmacokinetics of antiretrovirals and produce changes in plasma protein binding. The aim was to evaluate the pharmacokinetics of total and unbound lopinavir (LPV) in HIV-infected patients with and without hepatitis C virus (HCV) coinfection," investigators in Milan, Italy report.
"Fifty-six HIV+ patients receiving lopinavir/ritonavir (LPV/r) (group I=24 controls; II=23 HIV/HCV-coinfected; III=9 cirrhotic HIV/HCV-coinfected) were included.Total (n=56) and unbound (n=36) LPV pharmacokinetic parameters...
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Source: AIDS Weekly (2008-06-23)
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