HIV/AIDS
Reports on HIV/AIDS findings from Colorado State University provide new insights
Published in AIDS Weekly, June 30th, 2008
According to recent research published in the journal Human Gene Therapy, "Species-specific innate resistance against viral infections offers novel avenues for antiviral therapeutics. The retroviral restriction factor TRIM5 alpha ( tripartite motif 5 alpha protein) has been shown to potently restrict human immunodeficiency virus (HIV)-1 infection in otherwise susceptible cell lines and CD34(+) cell- derived macrophages."
"A 13-amino acid patch in the C-terminal B30.2 ( SPRY) domain of rhesus macaque TRIM5 alpha has been shown to be involved in HIV-1 capsid recognition and is critical for viral inhibition. A chimeric human - rhesus TRIM5 alpha ( TRIM5 alpha-HRH)...
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Source: AIDS Weekly (2008-06-30)
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