HIV/AIDS

Studies from A. Salim et al in the area of HIV/AIDS described

Published in AIDS Weekly, June 30th, 2008

According to recent research published in the Journal of Virology, "Vpu (viral protein U) is a 17-kDa human immunodeficiency virus type 1 (HIV-1) accessory protein that enhances the release of particles from the surfaces of infected cells. Vpu recruits beta-transducin repeat-containing protein (beta-TrCP) and mediates proteasomal degradation of CD4."

"By sequestering beta-TrCP away from other cellular substrates, Vpu leads to the stabilization of beta-TrCP substrates such as beta-catenin, I kappa B alpha, ATF4, and Cdc25A, but not of other substrates such as Emi1. This study shows that in addition to stabilizing beta-catenin, Vpu leads to the depression of both...

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Source: AIDS Weekly (2008-06-30)

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