HIV/AIDS
New findings in HIV/AIDS described from Kitasato University
Published in AIDS Weekly, July 14th, 2008
According to a study from Shirokane, Japan, "Myristoylation of human immunodeficiency virus (HIV) Gag protein is essential for membrane targeting of Gag and production of viral particles. We show here that coexpression of wild-type and nonmyristoylated forms of HIV Gag resulted in severe inhibition of viral particle production, indicating that the nonmyristoylated counterpart had a dominant negative effect on particle release."
"When coexpressed, the nonmyristoylated Gag partially incorporated into membrane and lipid raft fractions, likely through coassembly with the wild-type Gag. The membrane and raft associations of the wild-type Gag appeared unaffected, and yet...
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Source: AIDS Weekly (2008-07-14)
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