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HIV/AIDS Therapy

Researchers at Srinakharinwirot University, Faculty of Pharmacy release new data on HIV/AIDS therapy

Published in AIDS Weekly, August 4th, 2008

New investigation results, '3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors: application of molecular field analysis,' are detailed in a study published in Archiv Der Pharmazie. "Three-dimensional quantitative structure-activity relationship (3D-QSAR) models were developed for chromone derivatives against HIV-1 protease using molecular field analysis (MFA) with genetic partial least square algorithms (G/PLS). Three different alignment methods: field fit, pharmacophore-based, and receptor-based were used to derive three MFA models," investigators in Thailand report.

"All models produced good predictive ability with high cross-validated r(2)...

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