Antiretrovirals

Research on antiretrovirals reported by L. Schueller et al

Published in AIDS Weekly, August 4th, 2008

"A dog model was developed to test the capacity of boosters for antiretroviral medication. Two dogs were implanted with a modified constant-flow Codman 3000 (R) infusion pump, adapted to release viscous solutions of darunavir (TMC 114) at a constant rate of 25 mg/dog/day in the venous blood stream," investigators in Mechelen, Belgium report.

"Booster candidates were given by oral gavage for at least 4 days up to maximum 7 days in cross-over fashion, separated by a wash-out period of minimum I week. The booster candidates were tested at doses of 20 and/or 40 mg/kg/day: blood sampling for determination of the boosting effect was performed on the last day of booster...

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Source: AIDS Weekly (2008-08-04)

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