HIV/AIDS
New HIV/AIDS findings from A. Schneidewind and co-researchers published
Published in AIDS Weekly, August 11th, 2008
"Control of human immunodeficiency virus type 1 (HIV-1) by HLA-B27-positive subjects has been linked to an immunodominant CD8(+) cytotoxic T-lymphocyte (CTL) response targeting the conserved KK10 epitope (KRWIILGLNK(263-272)) in p24/Gag. Viral escape in KK10 typically occurs through development of an R264K substitution in conjunction with the upstream compensatory mutation S(173)A, and the difficulty of the virus to escape from the immune response against the KK10 epitope until late in infection has been associated with slower clinical progression," scientists writing in the Journal of Virology report.
"Rare alternative escape mutations at R-264 have been...
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Source: AIDS Weekly (2008-08-11)
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