HIV/AIDS
Findings from J. Dietz et al in HIV/AIDS reported
Published in AIDS Weekly, August 18th, 2008
According to a study from Frankfurt, Germany, "The interaction of the nucleocapsid NCp7 of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein with the RNA packaging signal Psi ensures specific encapsidation of the dimeric full length viral genome into nascent virus particles. Being on essential step in the HIV-1 replication cycle, specific genome encapsidation represents a promising target for therapeutic intervention."
"We previously selected peptides binding to HIV-7 Psi-RNA or stem loops (SL) thereof by phage display. Herein, we describe synthesis of peptide variants of the consensus HWWPWW motif on membrane supports to optimize Psi-RNA binding. The...
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Source: AIDS Weekly (2008-08-18)
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