HIV/AIDS

Researchers from University of Maryland report recent findings in HIV/AIDS

Published in AIDS Weekly, September 1st, 2008

"The role of plasmacytoid dendritic cells (pDC) and interferon alpha (IFN alpha) in HIV-1 infection is still unclear. On one hand, HIV-1 disease is associated with a progressive decline of pDC, which displays reduced ability to produce IFN alpha after in vitro challenge," investigators in the United States report.

"On the other hand, high IFNa serum levels in HIV-1-infected individuals have been proposed to promote immune hyper-activation and disease progression. We sought to determine whether disappearance of pDC in HIV-1 disease is due to homing in lymphoid tissues. We also studied IFN alpha and myxovirus resistance protein A (MxA) expression in unstimulated pDC and...

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Source: AIDS Weekly (2008-09-01)

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