HIV/AIDS Therapy
Research in the area of HIV/AIDS therapy reported from McGill University
Published in AIDS Weekly, September 8th, 2008
Investigators publish new data in the report 'Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.' "Thymidine analogue-associated mutations (TAMs) in reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1) cause resistance to 3'-azido-3'-deoxythymidine (AZT) through excision of the incorporated monophosphate. Mutations in the connection domain of HIV-1 RT can augment AZT resistance," scientists in Montreal, Canada report.
"It has been suggested that these mutations compromise RNase H cleavage, providing more time for...
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Source: AIDS Weekly (2008-09-08)
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