Gene Therapy
New gene therapy study findings reported from V. Bezzerri and co-authors
Published in AIDS Weekly, September 15th, 2008
"Chronic pulmonary inflammation in patients affected by cystic fibrosis (CF) is characterized by massive bronchial infiltrates of neutrophils, which is sustained by the interaction of pathogens (e.g., Pseudomonas aeruginosa) with surface bronchial cells. To explore new treatment options focused on the reduction of neutrophil chemotaxis, we applied the transcription factor (TF) decoy approach, based on the intracellular delivery of double-stranded oligodeoxynucleotides (ODNs) causing inhibition of the binding of TF-related proteins to the different consensus sequences in the promoter of specific genes," scientists in Ferrara, Italy report.
"In CF bronchial IB3-1 cells,...
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Source: AIDS Weekly (2008-09-15)
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