HIV/AIDS

Scientists at Federal University release new data on HIV/AIDS

Published in AIDS Weekly, October 6th, 2008

"The I50V protease inhibitor (PI) resistance mutation was found in 87.4% of protease gene fragments sequenced from 199 nucleic acid isolates extracted using an NASBA virus load assay, performed between 1997 and 2001 in Brazil. This mutation is an amprenavir-related mutation, and at that particular time this PI was seldom used in Brazil," researchers in Brazil report.

"This mutation was found both in patients with and without therapeutic success. Q calibrators showed the PI resistance mutation I50V when directly amplified and sequenced from the 423-bp PCR product targeting protease gene. The majority of the patients' samples had a mixture of I50I and I50V; however, this...

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Source: AIDS Weekly (2008-10-06)

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