HIV/AIDS

Researchers at University of Foggia target HIV/AIDS

Published in AIDS Weekly, October 6th, 2008

"The extent to which HIV-1 proviral DNA mutations cause clinically relevant antiretroviral resistance is still controversial. Paired plasma HIV-1 RNA and whole blood DNA were compared in patients failing HAART to investigate if the additional knowledge of archived mutations could improve the selection of potentially active drugs," researchers in Foggia, Italy report.

"Seventy-three HIV-1-infected patients with first/second HAART failure were studied before starting a new regimen based on RNA genotyping. Follow-up data after a 12-week therapy were available. DNA genotyping was retrospectively performed on stored whole blood samples and mutational profiles were compared...

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Source: AIDS Weekly (2008-10-06)

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