HIV/AIDS

New findings from Case Western Reserve University, Medical Department in the area of HIV/AIDS described

Published in AIDS Weekly, October 27th, 2008

According to recent research from the United States, "The positive transcription elongation factor b (P-TEFb) is an essential cellular cofactor for the transcription of the human immunodeficiency virus type 1 (HIV-1). The cyclin TI (CycT1) subunit of P-TEFb associates with a viral protein, Tat, at the transactivation response element (TAR)."

"This represents a critical and necessary step for the stimulation of transcriptional elongation. Therefore, CycT1 may serve as a potential target for the development of anti-HIV therapies. To create effective inhibitors of HIV transcription, mutant CycT1 proteins were constructed based upon sequence similarities between CycT1 and...

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Source: AIDS Weekly (2008-10-27)

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