HIV/AIDS
New HIV/AIDS data have been reported by K.A. Delviksfrankenberry and co-authors
Published in AIDS Weekly, October 27th, 2008
According to a study from the United States, "We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn mutations in combination with thymidine analog mutations (D67N, K70R, T215Y, and K219Q) on in vitro RNase H activity and AZT monophosphate (AZTMP) excision."
"We found that cn mutations G335C/D, N348I, A360I/V, V365I, and A376S decreased primary and secondary RNase H cleavages. The patient-derived cns increased ATP- and...
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Source: AIDS Weekly (2008-10-27)
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