HIV/AIDS
Research conducted at University of Leuven has provided new information about HIV/AIDS
Published in AIDS Weekly, October 27th, 2008
According to recent research from Belgium, "We have identified 1H-benzylindole analogues as a novel series of human immunodeficiency virus (HIV) integrase inhibitors with antiretroviral activities against different strains of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strain MAC(251) [SIV(MAC(251))]. Molecular modeling and structure-activity relationship-based optimization resulted in the identification of CHI/1043 as the most potent congener."
"CHI/1043 inhibited the replication of HIV-1(IIIB) in MT-4 cells at a 50% effective concentration (EC50) of 0.60 mc M, 70-fold below its cytotoxic concentration. Equal activities against HIV-1(NL4.3),...
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Source: AIDS Weekly (2008-10-27)
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