AIDS Weekly
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HIV/AIDS Cancer
Reports from University of Washington describe recent advances in HIV/AIDS cancer
November 3rd, 2008
According to recent research from the United States, "Kaposi's sarcoma (KS) is the most common tumor of AIDS patients worldwide. KS-associated herpesvirus (KSHV) is the infectious cause of this highly vascularized skin tumor." "The main cell type found within a KS lesion, the spindle cell, is latently infected with KSHV and has markers of both blood and lymphatic endothelial cells. During development, lymphatic endothelial cells differentiate from preexisting blood endothelial cells. Interestingly, KSHV infection of blood endothelial cells induces lymphatic endothelial cell differentiation. Here, we show that KSHV gene expression is necessary to maintain the expression...
Source: AIDS Weekly (2008-11-03)
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