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HIV/AIDS Therapy
Data from Kyoto University provide new insights into HIV/AIDS therapy
November 3rd, 2008
Fresh data on HIV/AIDS are presented in the report 'Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.' "Entry of human immunodeficiency virus type 1 (HIV-1) into target cells is mediated by its envelope protein gp41 through membrane fusion. Interaction of two extra-virion heptad repeats (HRs) in the gp41 plays a pivotal role in the fusion, and its inhibitor, enfuvirtide (T-20), blocks HIV-1 entry," scientists in Kyoto, Japan report. "To identify agents that block HIV-1 fusion, two screening methods based on detection and quantification by the enzyme-linked immunosorbent assay (ELISA) principle have been established. One method...
Source: AIDS Weekly (2008-11-03)
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