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Diabetes
Investigators at National Institute of Diabetes and Digestive and Kidney Disease release new data on diabetes
November 3rd, 2008
"HIV- 1 protease processes the Gag and Gag- Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation(1,2). The mature protease is active only as a dimer(3-5) with each subunit contributing catalytic residues(6)," scientists in the United States report. "The full- length transframe region protease precursor appears to be monomeric yet undergoes maturation via intramolecular cleavage of a putative precursor dimer(5,7-11), concomitant with the appearance of mature- like catalytic activity(7,9). How such intramolecular cleavage can occur when the amino and carboxy termini of the mature protease...
Source: AIDS Weekly (2008-11-03)
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