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DNA Vaccines
Data on DNA vaccines discussed by researchers at University of Colorado
November 3rd, 2008
"A DNA vaccine encoding sequence-conserved human immunodeficiency virus type 1 (HIV-1)-derived cytotoxic T-lymphocyte (CTL) epitopes from multiple HIV-1 gene products (designated EP HIV-1090) was evaluated in a placebo-controlled, dose escalation phase 1 clinical trial of HIV-1-infected subjects receiving potent combination antiretroviral therapy. Patients received four intramuscular immunizations with EP HIV-1090 over a 4-month period at one of four doses (0.5, 1.0, 2.0, or 4.0 mg) or received a placebo," researchers in the United States report. "The vaccine was determined to be safe and well tolerated at all doses tested. CTL responses were measured from cryopreserved...
Source: AIDS Weekly (2008-11-03)
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