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HIV/AIDS
Data on HIV/AIDS discussed by researchers at University of Erlangen
November 3rd, 2008
"Plasmacytoid dendritic cells (PDC) are major producers of type I interferons (IFN) in response to human immunodeficiency virus type I (HIV-1) infection," investigators in Erlangen, Germany report. "To better define the underlying mechanisms, we studied the magnitude of alpha IFN (IFN-alpha) induction by recombinant viruses containing changes in the Env protein that impair or disrupt CD4 binding or expressing primary env alleles with differential coreceptor tropism. We found that the CD4 binding affinity but not the viral coreceptor usage is critical for the attachment of autofluorescing HIV-1 to PDC and for subsequent IFN-alpha induction," wrote S. Haupt and...
Source: AIDS Weekly (2008-11-03)
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