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HIV/AIDS
Findings from P.C. Matthews and co-authors provide new insights into HIV/AIDS
November 3rd, 2008
According to recent research published in the Journal of Virology, "Much uncertainty still exists over what T-cell responses need to be induced by an effective human immunodeficiency virus (HIV) vaccine. Previous studies have hypothesized that the effective CD8(+) T-cell responses are those driving the selection of escape mutations that reduce viral fitness and therefore revert posttransmission." "In this study, we adopted a novel approach to define better the role of reverting escape mutations in immune control of HIV infection. This analysis of sequences from 710 study subjects with chronic C-clade HIV type I infection demonstrates the importance of mutations...
Source: AIDS Weekly (2008-11-03)
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