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HIV/AIDS
Investigators at National Institutes of Health release new data on HIV/AIDS
November 3rd, 2008
"Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody responses through mechanisms that remain poorly defined. A unique memory B cell subpopulation (CD20(hi)/CD27(lo)/CD21(lo)) in human tonsillar tissues was recently defined by the expression of the inhibitory receptor Fc-receptor-like-4 (FCRL4)," scientists in the United States report. "In this study, we describe a similar B cell subpopulation in the blood of HIV-viremic individuals. FCRL4 expression was increased on B cells of HIV-viremic compared with HIV-aviremic and HIV-negative individuals. It was enriched on B cells with a tissuelike memory phenotype ( CD20(hi)/CD27(lo)/CD21(lo)) when...
Source: AIDS Weekly (2008-11-03)
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