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HIV/AIDS
New HIV/AIDS research from Yale University described
November 3rd, 2008
According to recent research published in the Journal of Virology, "Human immunodeficiency virus (HIV) virion infectivity factor (Vif) causes the proteasome-mediated destruction of human antiviral protein APOBEC3G by tethering it to a cellular E3 ubiquitin ligase composed of ElonginB, ElonginC, Culfin5, and Rbx2. It has been proposed that HIV Vif hijacks the E3 ligase through two regions within its C-terminal domain: a BC box region that interacts with EllonginC and a novel zinc finger motif that interacts with Culfin5." "We have determined the crystal structure of the HIV Vif BC box in complex with human ElonginB and ElonginC. This complex presents direct...
Source: AIDS Weekly (2008-11-03)
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