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HIV/AIDS
Reports from J.A. Zahm et al highlight recent research in HIV/AIDS
November 3rd, 2008
According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "The ''strand transfer inhibitors'' of human immunodeficiency virus type-1 (HIV-1) integrase (IN), so named because of their pronounced selectivity for inhibiting strand transfer over 3' OH processing, block virus replication in vivo and ex vivo and prevent concerted integration in vitro. We explored the kinetics of product formation and strand transfer inhibition within reconstituted synaptic complexes capable of concerted integration." "Synaptic complexes were formed with viral DNA donors containing either two blunt ends, two 3'-OH-processed ends, or one of each. We...
Source: AIDS Weekly (2008-11-03)
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