Published in AIDS Weekly, November 3rd, 2008
"In this study, we show that recombinant PR containing a single I47A substitution has the inhibition constant (K-i) value for lopinavir by two orders of magnitude higher than for the wild-type PR. The addition of the I47A substitution to the background of a multiply mutated PR species from an AIDS patient showed a...
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Source: AIDS Weekly (2008-11-03)
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