HIV/AIDS

Research on HIV/AIDS reported by scientists at University of Verona

Published in AIDS Weekly, November 17th, 2008

According to recent research published in the journal Retrovirology, "A recently identified genetic polymorphism located in the 5 ' region of the HLA-C gene is associated with individual variations in HIV-1 viral load and with differences in HLA-C expression levels. HLA-C has the potential to restrict HIV-1 by presenting epitopes to cytotoxic T cells but it is also a potent inhibitor of NK cells."

"In addition, HLA-C molecules incorporated within the HIV-1 envelope have been shown to bind to the envelope glycoprotein gp120 and enhance viral infectivity. We investigated this last property in cell fusion assays where the expression of HLA-C was silenced by small...

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Source: AIDS Weekly (2008-11-17)

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