DNA Research

New DNA research study findings have been published by scientists at University of Wisconsin

Published in AIDS Weekly, December 22nd, 2008

According to recent research from the United States, "Bacterial DNA transposition is an important model system for studying DNA recombination events such as HIV-1 DNA integration and RAG-1-mediated V(D)J recombination. This communication focuses on the role of protein-phosphate contacts in manipulating DNA structure as a requirement for transposition catalysis."

"In particular, the participation of the nontransferred strand (NTS) 5' phosphate in Tn5 transposition strand transfer is analyzed. The 5' phosphate plays no direct catalytic role, nonetheless its presence stimulates strand transfer similar to 30-fold. X-ray crystallography indicates that transposase-DNA...

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Source: AIDS Weekly (2008-12-22)

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