HIV/AIDS

New HIV/AIDS findings from Shanghai Jiao Tong University described

Published in AIDS Weekly, December 22nd, 2008

According to recent research from Shanghai, People's Republic of China, "HIV-1 reverse transcriptase is a key enzyme playing an important role in the HIV-1 life cycle for the replication of the RNA genome into DNA form. Lys103Asn (K103N) mutant frequently is observed in HIV-1 reverse transcriptase."

"Therefore, a series of novel non-nucleoside reverse transcriptase inhibitors were designed and synthesized. In vitro experimental results show that diaryltriazine analogs have potent anti-HIV activity with moderate to high selectivity. In order to design anti-HIV drug, docking and molecular dynamics simulation were used to investigate the binding mode between ligand and...

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Source: AIDS Weekly (2008-12-22)

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