HIV/AIDS
Reports summarize HIV/AIDS study results from University of Utah
Published in AIDS Weekly, January 12th, 2009
"The rhesus monkey intrinsic immunity factor TRIM5 alpha(rh) recognizes incoming capsids from a variety of retroviruses, including human immunodeficiency virus type 1 (HIV-1) and equine infectious anemia virus (EIAV), and inhibits the accumulation of viral reverse transcripts. However, direct interactions between restricting TRIM5 alpha proteins and retroviral capsids have not previously been demonstrated using pure recombinant proteins," scientists in the United States report.
"To facilitate structural and mechanistic studies of retroviral restriction, we have developed methods for expressing and purifying an active chimeric TRIM5 alpha(rh) protein containing the RING...
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Source: AIDS Weekly (2009-01-12)
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