Published in AIDS Weekly, February 16th, 2009
"We have previously shown that, the HIV envelope glycoprotein gp120 used at levels similar those in plasmas of untreated HIV+ patients, induced expression of the osteoclast (OC) differentiation factor RANKL in CD4+ T cells. in addition, the HIV PI ritonavir abrogated the interferon-gamma-mediated degradation of the RANKL nuclear adapter protein TRAF6, a physiological block to...
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