HIV/AIDS

New findings from J. Kadas and co-researchers in the area of HIV/AIDS described

Published in AIDS Weekly, February 16th, 2009

According to recent research published in the Biochemical Journal, "HTLV-1 [HTLV (human T-cell lymphotrophic virus) type 1] is associated with a number of human diseases. HTLV-1 protease is essential for virus replication, and similarly to HIV-1 protease, it is a potential target for chemotherapy."

"The primary sequence of HTLV-1 protease is substantially longer compared with that of HIV-1 protease, and the role of the ten C-terminal residues is controversial. We have expressed C-terminally-truncated forms of HTLV-1 protease with and without N-terminal His tags. Removal of five of the C-terminal residues caused a 4-40-fold decrease in specificity constants,...

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Source: AIDS Weekly (2009-02-16)

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