Published in AIDS Weekly, February 23rd, 2009
"HIV single-stranded RNA is a potent immune activator by triggering Toll-like receptor (TLR) 7/8. Thus, we hypothesized that sustained TLR7 triggering induces chronic immune activation and thereby contributes to progressive immunodeficiency. We used the synthetic compound R848 or a mixture of uridine-rich HIV single-stranded (ss) RNA oligonucleotides-both are potent TLR7/8 agonists-to explore the effects of sustained TLR7 triggering on...
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