Published in AIDS Weekly, March 2nd, 2009
"One strategy to enhance the efficiency of DNA vaccines is to augment effector T-cell priming against viral components by manipulating regulatory T-cell functions (Treg). Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a molecule that is constitutively expressed on CD4(+) Treg cells, and antibodies or natural ligands binding this molecule can impair...
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