HIV/AIDS

Researchers from Pennsylvania State University, Medical Department publish new studies and findings in the area of HIV/AIDS

Published in AIDS Weekly, March 2nd, 2009

According to recent research from the United States, "HIV anti-retroviral drugs decrease protein synthesis, although the underlying regulatory mechanisms of this process are not fully established. Therefore, we investigated the effects of the HIV protease inhibitor lopinavir (LPV) on protein metabolism."

"We also characterized the mechanisms that mediate the effects of this drug on elongation factor-2 (eEF2), a key component of the translational machinery. Treatment of C2C 12 myocytes with LPV produced a dose-dependent inhibitory effect on protein synthesis. This effect was observed at 15 min and was maintained for at least 4 h. Mechanistically, LPV increased the...

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Source: AIDS Weekly (2009-03-02)

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